Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 13, Issue 7, Pages 1033-1049Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2009.2930
Keywords
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Funding
- Canadian Institute of Circulatory and Respiratory Health
- Northern Ontario School of Medicine
- CIHR/HSFC
- Heart and Stroke Foundation of Ontario
- Manitoba Health Research Council
- St. Boniface Hospital & Research Foundation
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Oxidative stress and inflammation are each implicated independently in the development and progression of heart failure. Their interaction, however, is also evident throughout the process from initial injury to cardiac remodeling and failure. In the failing heart, the linkage between excessive reactive oxygen species (ROS) and the cytokine elaboration is manifested in shared elements and cross-promotion within downstream signaling pathways. In spite of this, the failure of anticytokine immunotherapy and antioxidant therapy, which had previously shown promise, suggests that a more complete perspective of ROS-cytokine interaction is required. The present review focuses on two of the major cytokines that are demonstrably connected to oxidative stress-the pro-inflammatory tumor necrosis factor-alpha (TNF-alpha) and the anti-inflammatory interleukin-10 (IL-10)- and their interactions in cardiac remodeling and failure. It is proposed that an optimal balance between TNF-alpha and IL-10 may be of crucial importance in mitigating both inflammation and oxidative stress processes leading to heart failure. Antioxid. Redox Signal. 13, 1033-1049.
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