Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 11, Issue 3, Pages 497-508Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2008.2242
Keywords
-
Funding
- NIEHS [RO1 ES 10042, ES 08089]
- Amyotrophic Lateral Sclerosis Association
- Packard Center for ALS Research
- Hereditary Disease Foundation
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES010042, R29ES008089, R01ES008089] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor known to induce expression of a variety of cytoprotective and detoxification genes. Several of the genes commonly regulated by Nrf2 have been implicated in protection from neurodegenerative conditions. Work from several laboratories has uncovered the potential for Nrf2-mediated transcription to protect from neurodegeneration resulting from mechanisms involving oxidative stress. For this reason, Nrf2 may be considered a therapeutic target for conditions that are known to involve free radical damage. Because common mechanisms of neurodegeneration, such as mitochondrial dysfunction and build-up of reactive oxygen species, are currently being uncovered, targeting Nrf2 may be valuable in combating conditions with variable causes and etiologies. Most effectively to target this protein in neurodegenerative conditions, a description of the involvement of Nrf2 and potential for neuroprotection must come from laboratory models. Herein, we review the current literature that suggests that Nrf2 may be a valuable therapeutic target for neurodegenerative disease, as well as experiments that illustrate potential mechanisms of protection. Antioxid. Redox Signal. 11, 497-508.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available