Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 11, Issue 9, Pages 2151-2166Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2009.2460
Keywords
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Funding
- NINDS NIH HHS [R01 NS034239, R01 NS034239-14, R01 NS036126] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034239, R01NS036126] Funding Source: NIH RePORTER
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Innate and adaptive immunity affect the pathogenesis of Parkinson's disease (PD). In particular, activation of microglia influences degeneration of dopaminergic neurons. Cell-to-cell interactions and immune regulation critical for neuronal homeostasis also influence immune responses. The links between T cell immunity and nigrostriatal degeneration are supported by laboratory, animal model, and human pathologic investigations. Immune-associated biomarkers in spinal fluids and brain tissue of patients with idiopathic or familial forms of PD provide means to improve diagnosis and therapeutic monitoring. Relationships between oxidative stress, inflammation, and immune-mediated cell death pathways are examined in this review as they are linked to PD pathogenesis. Harnessing the immune system by drugs or by vaccination remain promising future therapeutic options. Antioxid. Redox Signal. 11, 2151-2166.
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