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R Wu et al.
CIRCULATION (2002)
p53 mutant mice that display early ageing-associated phenotypes
SD Tyner et al.
NATURE (2002)
Signals of oxidant-induced cardiomyocyte hypertrophy: Key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase
VC Tu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Modulation of cell injury and survival by high glucose and advancing age
NK Fukagawa et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts
C Petropoulou et al.
FEBS LETTERS (2001)
Oxidative stress and vascular aging
BP Yu et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2001)
Homocysteine impairs the nitric oxide synthase pathway -: Role of asymmetric dimethylarginine
MC Stühlinger et al.
CIRCULATION (2001)
eNOS activity is reduced in senescent human endothelial cells - Preservation by hTERT immortalization
H Matsushita et al.
CIRCULATION RESEARCH (2001)
cRel induces mitochondrial alterations in correlation with proliferation arrest
D Bernard et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
A Krtolica et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts
K Nishio et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2001)
N-t-butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro
H Atamna et al.
FASEB JOURNAL (2001)
Switching and signaling at the telomere
EH Blackburn
CELL (2001)
Telomere shortening in atherosclerosis
NJ Samani et al.
LANCET (2001)
Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
M Wagner et al.
EXPERIMENTAL GERONTOLOGY (2001)
Caveolin-1 expression negatively regulates cell cycle progression by inducing G0/G1 arrest via a p53/p21WAF1/Cip1-dependent mechanism
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MOLECULAR BIOLOGY OF THE CELL (2001)
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
FQ Schafer et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Current perspective on the role of apoptosis in atherothrombotic disease
Z Mallat et al.
CIRCULATION RESEARCH (2001)
From cells to organisms: can we learn about aging from cells in culture?
J Campisi
EXPERIMENTAL GERONTOLOGY (2001)
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
A Ito et al.
EMBO JOURNAL (2001)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
HA Tissenbaum et al.
NATURE (2001)
Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
V Paradis et al.
HUMAN PATHOLOGY (2001)
Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity
NS Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Differential expression of thymosin β-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF:: evidence for senescent endothelial cells in vivo at sites of atherosclerosis
E Vasile et al.
FASEB JOURNAL (2001)
Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries
M Fenton et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2001)
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase-1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Subcytotoxic H2O2 stress triggers a release of transforming growth factor-β1, which induces biomarkers of cellular senescence of human diploid fibroblasts
C Frippiat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation
B Razani et al.
BIOCHEMISTRY (2000)
Unregulated inflammation shortens human functional longevity
SA Brod
INFLAMMATION RESEARCH (2000)
Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?
T von Zglinicki et al.
LABORATORY INVESTIGATION (2000)
Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts
CG Tepper et al.
EXPERIMENTAL CELL RESEARCH (2000)
Mitochondria, oxygen free radicals, disease and ageing
S Raha et al.
TRENDS IN BIOCHEMICAL SCIENCES (2000)
The Rb/E2F pathway: expanding roles and emerging paradigms
JW Harbour et al.
GENES & DEVELOPMENT (2000)
Nitric oxide activates telomerase and delays endothelial cell senescence
M Vasa et al.
CIRCULATION RESEARCH (2000)
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
SJ Lin et al.
SCIENCE (2000)
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
S Matsuoka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Cell cycle regulation in H2O2-induced premature senescence of human diploid fibroblasts and regulatory control exerted by the papilloma virus E6 and E7 proteins
C Frippiat et al.
EXPERIMENTAL GERONTOLOGY (2000)
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
V Dulic et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Cellular senescence: Mitotic clock or culture shock?
CJ Sherr et al.
CELL (2000)
Atmospheric carbon dioxide concentrations over the past 60 million years
PN Pearson et al.
NATURE (2000)
Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress
S Kurata
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mitochondrial free radical generation, oxidative stress, and aging
E Cadenas et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Regulation of genes encoding NAD(P)H:quinone oxidoreductases
AK Jaiswal
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Telomere length inversely correlates with pulse pressure and is highly familial
E Jeanclos et al.
HYPERTENSION (2000)
Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells
WY Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery
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JOURNAL OF SURGICAL RESEARCH (2000)
Expression of senescence-associate beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia
J Choi et al.
UROLOGY (2000)
Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
HC Lee et al.
BIOCHEMICAL JOURNAL (2000)
Is β-galactosidase staining a marker of senescence in vitro and in vivo?
J Severino et al.
EXPERIMENTAL CELL RESEARCH (2000)
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
K Webley et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Homocysteine accelerates endothelial cell senescence
D Xu et al.
FEBS LETTERS (2000)
N-t-butyl hydroxylamine, a hydrolysis product of α-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts
H Atamna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Telomere reduction in human liver tissues with age and chronic inflammation
H Aikata et al.
EXPERIMENTAL CELL RESEARCH (2000)
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
SL Friedman
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle
TA Zainal et al.
FASEB JOURNAL (2000)
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
T Von Zglinicki et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
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