Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 11, Issue 9, Pages 2353-2364Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2008.2391
Keywords
-
Ask authors/readers for more resources
Endoplasmic reticulum (ER) stress induces an adaptive program called the unfolded protein response (UPR), which affects activity of an array of kinases and transcription factors. Previous reports provided evidence for activation of nuclear factor-kappa B (NF-kappa B), the major transcription factor regulating inflammatory processes, by ER stress. However, recent investigation also suggested that preceding ER stress suppresses activation of NF-kappa B by subsequent exposure to inflammatory stimuli. Although ER stress induces activation of NF-kappa Bin the early phase, consequent UPR may inhibit NF-kappa B-dependent cellular activation in the later phase. This article summarizes current knowledge on potential mechanisms underlying the biphasic, bidirectional regulation of NF-kappa B by ER stress. Antioxid. Redox Signal. 11, 2353-2364.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available