Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 11, Issue 6, Pages 1357-1372Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2008.2365
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Funding
- American Heart Association
- Ellison Medical Foundation
- National Institutes of Health
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Membrane (lipid) rafts and caveolae, a subset of rafts, are cellular domains that concentrate plasma membrane proteins and lipids involved in the regulation of cell function. In addition to providing signaling platforms for G-protein-coupled receptors and certain tyrosine kinase receptors, rafts/caveolae can influence redox signaling. This review discusses molecular characteristics of and methods to study rafts/caveolae, determinants that contribute to the localization of molecules in these entities, an overview of signaling molecules that show such localization, and the contribution of rafts/caveolae to redox signaling. Of particular note is the evidence that endothelial nitric oxide synthase (eNOS), NADPH oxygenase, and heme oxygenase, along with other less well-studied redox systems, localize in rafts and caveolae. The precise basis for this localization and the contribution of raft/caveolae-localized redox components to physiology and disease are important issues for future studies. Antioxid. Redox Signal. 11, 1357-1372.
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