Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 10, Issue 4, Pages 799-811Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2007.1938
Keywords
-
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL092842, R01HL085613] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES001247] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL085613, R01 HL092842, R01 HL 085613, R01 HL085613-02, R01 HL085613-01A2] Funding Source: Medline
- NIEHS NIH HHS [ES 07026, ES 01247, P30 ES001247, T32 ES007026, R01 ES007026] Funding Source: Medline
Ask authors/readers for more resources
Oxidative stress has been implicated in the pathogenesis of several inflammatory lung disorders including chronic obstructive pulmonary disease (COPD), due to its effect on pro-inflammatory gene transcription. Cigarette smoke-mediated oxidative stress activates NF-kappa B-dependent transcription of pro-inflammatory mediators either through activation of inhibitor kappa B-alpha kinase (IKK) and/or the enhanced recruitment and activation of transcriptional co-activators. Enhanced NF-kappa B-co-activator complex formation results in targeted increase in chromatin modifications, such as histone acetylation leading to inflammatory gene transcription. NF-kappa B-dependent gene expression, at least in part, is regulated by changes in deacetylases such as histone deacetylases (HDACs) and sirtuins. Cigarette smoke and oxidants also alter the activity of HDACs and sirtuins by post-translational modifications by protein carbonylation and nitration, and in doing so further induce gene expression of pro-inflammatory mediators by chromatin modifications. In addition, cigarette smoke/oxidants can reduce glucocorticoid sensitivity by attenuating HDAC2 activity and expression, which may account for the glucocorticoid insensitivity in patients with COPD. Understanding the mechanisms of NF-kappa B regulation, and the balance between histone acetylation and deacetylation may lead to the development of novel therapies based on the pharmacological manipulation of IKK and deacetylases in lung inflammation and injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available