Journal
PHYSIOLOGICAL REVIEWS
Volume 85, Issue 4, Pages 1131-1158Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00015.2004
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- Wellcome Trust Funding Source: Medline
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Our knowledge of the physiological systems controlling energy homeostasis has increased dramatically over the last decade. The roles of peripheral signals from adipose tissue, pancreas, and the gastrointestinal tract reflecting short- and long-term nutritional status are now being described. Such signals influence central circuits in the hypothalamus, brain stem, and limbic system to modulate neuropeptide release and hence food intake and energy expenditure. This review discusses the peripheral hormones and central neuronal pathways that contribute to control of appetite.
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