Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 94, Issue 10, Pages 2132-2134Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/jps.20459
Keywords
excipients; crystallinity; mechanical properties; tableting; powder technology
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Microcrystalline cellulose (MCC) exhibits unusual tableting properties, sometimes, inconsistent with its high plasticity. It is found that some of the unusual tableting properties of MCC can be explained in part by the use of inaccurate true density during tableting data analysis. MCC true density as a function of water content is determined using a published method that can determine true density of water containing solids. Results suggest that literature MCC true densities tend to be overestimated as a result of limitations in helium pycnometry. (c) 2005 Wiley-Liss, Inc.
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