Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 7, Pages 4593-4602Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.7.4593
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Funding
- NIAID NIH HHS [P01AI056296] Funding Source: Medline
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A sustained CD4(+) Th1-dominated type I immune response is required to successfully control Mycobacterium tuberculosis infection. Considerable work has demonstrated that the transcription factor, T-bet, is required for IFN-gamma expression and fundamental to the generation of type 1 immunity in multiple cell types. Mice lacking T-bet are susceptible to virulent M. tuberculosis infection. Susceptibility of T-bet-deficient mice is associated with increased systemic bacterial burden, diminished IFN-gamma production, and the striking accumulation of eosinophilic macrophages and multinucleated giant cells in the lung. Interestingly, T-bet(-/-) mice did not develop a fully polarized Th2 response toward M. tuberculosis, but exhibited selective elevation of IL-10 production. These results indicate that T-bet plays a central role in controlling M. tuberculosis disease progression, in part through the regulation of both IFN-gamma and IL-10.
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