Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 62, Issue 11, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01314-18
Keywords
mycobacteria; PBTZ169; susceptibility; DprE1
Categories
Funding
- Beijing Talents Foundation [2017000021223ZK39]
- Beijing Municipal Administration of Hospitals' Youth Programme [QML20171601]
- Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20181602]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201809]
- Capital's Funds for Health Improvement and Research [2016-4-1141]
Ask authors/readers for more resources
In this study, we demonstrate that PBTZ169 exhibits significant differences in in vitro activity against multiple Mycobacterium species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1) can be used as a surrogate marker for in vitro susceptibility to PBTZ169 in mycobacteria. In addition, the amino acid substitution at codon 154 in DprE1 may be associated with acquired resistance to PBTZ169 in the Mycobacterium fortuitum mutants.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
