Journal
NEUROLOGICAL RESEARCH
Volume 27, Issue 7, Pages 685-691Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/016164105X49463
Keywords
Alzheimer's disease; aging; brain tumors; amyotrophic lateral sclerosis
Categories
Funding
- NIA NIH HHS [AG023665] Funding Source: Medline
- NINDS NIH HHS [NS049185] Funding Source: Medline
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Microglial cells comprise a network of endogenous immunocompetent cells that pervade the brain and spinal cord. The primary function of this system is to provide continuous surveillance of the parenchyma and protect the central nervous system (CNS) during injury and disease. Here we discuss the involvement of microglia during brain aging and aging-related neurodegenerative disease, i.e. Alzheimer's disease, and briefly summarize their possible roles in amyotrophic lateral sclerosis (ALS). In addition, we provide an overview of the neuroinflammation associated with primary brain tumors and how microglial tumor cytotoxicity could be targeted for immunotherapeutic approaches designed to treat these lesions.
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