Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 2, Pages 1320-1324Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03695-14
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- National Major Science and Technology Project for the Prevention and Treatment of AIDS and Viral Hepatitis and Other Major Infectious Diseases [2012ZX10003002-001]
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p-Aminosalicylic acid (PAS) is an important compound for treating multidrug-resistant tuberculosis (TB). Previous studies showed that thyA mutations are often related to PAS resistance in clinical isolates. We performed a systematic analysis of isolate genotypes and detected mutations in three folate pathway genes (folC, thyA, and ribD) in 61.1% (127/208) of PAS-resistant isolates, including 11 double mutants. This result expands our knowledge about the distribution and frequency of mutations related to PAS resistance in mycobacterial clinical isolates.
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