Journal
FEBS JOURNAL
Volume 272, Issue 20, Pages 5169-5181Publisher
WILEY
DOI: 10.1111/j.1742-4658.2005.04939.x
Keywords
dynamin-related protein; dynamin; endoplasmic reticulum; GTPase; organelle division; peroxisome proliferator-activated receptor; peroxisome; PEX11; VPS1; yeast
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The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organelles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators, two groups of peroxisomal proteins have a pronounced influence on peroxisome size and abundance. Pex11-type peroxisome proliferators are involved in the proliferation of peroxisomes, defined here as an increase in size and/or number of peroxisomes. Dynamin-related proteins have recently been suggested to be required for the scission of peroxisomal membranes. This review surveys the function of Pex11-type peroxisome proliferators and dynamin-related proteins in peroxisomal proliferation and division.
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