Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 167, Issue 1-2, Pages 210-214Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.06.024
Keywords
multiple sclerosis; B cells; APRIL
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B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL-a promotor of B-cell survival-in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls. APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing-remitting MS, albeit not significantly. MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL. (C) 2005 Elsevier B.V. All rights reserved.
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