Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 58, Issue 11, Pages 6982-6985Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03808-14
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Funding
- National Natural Science Foundation of China [81102509, 81120108024, 81273559]
- Shanghai Municipal Science and Technology Commission [10ZR1405600]
- Innovation Personnel Training Plan of Key Discipline, Shanghai Medical College, Fudan University
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Of 26 tigecycline-nonsusceptible Klebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR). Eight TNSKP isolates possessed overexpression of ramA, acrB, rarA, and oqxB simultaneously, while 8 and 1 TNSKP strains had upregulation of ramA and acrB and of rarA and oqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolates cannot be explained by the present pathways. This study underscores the role of RamA in TNSKP and suggests the presence of novel tigecycline resistance mechanisms.
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