Journal
INFECTION AND IMMUNITY
Volume 73, Issue 10, Pages 7043-7046Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.10.7043-7046.2005
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Funding
- NIAID NIH HHS [K08 AI051526, R01 AI048935, 5 R01AI048935, K08 AI51526-01] Funding Source: Medline
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In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4(+) T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.
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