Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 1, Pages 730-733Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03908-14
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Funding
- Global Fund Grant Malaria Programme Round 9 [CAM-S10-G14-M]
- U.S. National Institutes of Health [R01AI103228]
- French Ministry of Foreign Affairs
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Polymorphism in the ortholog gene of the Plasmodium falciparum K13 gene was investigated in Plasmodium vivax isolates collected in Cambodia. All of them were Sal-1 wild-type alleles except two (2/284, 0.7%), and P. vivax K12 polymorphism was reduced compared to that of the P. falciparum K13 gene. Both mutant allele isolates had the same nonsynonymous mutation at codon 552 (V552I) and were from Ratanak Kiri province. These preliminary data should encourage additional studies for associating artemisinin or chloroquine resistance and K12 polymorphism.
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