Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 58, Issue 11, Pages 6999-7002Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03279-14
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Funding
- Science and Technology Planning Project of Hunan Province, China [2013SK2015]
- Excellent Youth Foundation of Hunan Province, China [14JJ1018]
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The resistance of multidrug-resistant Acinetobacter baumannii (MDRAB) isolates to most traditional antibiotics results in huge challenges for infection therapy. We investigated the in vitro activities of both L- and D-lycosin-I against MDRAB. These two compounds displayed high antibacterial activities and rapid bactericidal effects against MDRAB. Moreover, the compounds retained their activity even at high salt (Mg2+ or Ca2+) concentrations. These results demonstrate the potential of lycosin-I to be developed as a new antibiotic.
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