Journal
BLOOD
Volume 106, Issue 7, Pages 2543-2550Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2005-03-1239
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Funding
- NIGMS NIH HHS [R01GM62995] Funding Source: Medline
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Dectin-1 is a lectin receptor for beta-glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory cytokines. The, mechanisms by which Dectin-1 mediates intracellular signaling are just beginning to, be defined. Spleen tyrosine kinase (Syk) is a protein, tyrosine kinase that is critical for adaptive immune responses where it mediates signaling through B-cell receptors, T-cell receptors, and Fc receptors. Here we report that Dectin-1 activates Syk in macrophages and is important for Dectin-1-stimulated reactive oxygen production, but not for phagocytosis. Syk activation is restricted to a subpopulation of macrophages; that is in equilibrium with cells that cannot activate the pathway. The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential.
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