4.5 Article

Microfluidic flow focusing: Drop size and scaling in pressure versus flow-rate-driven pumping

Journal

ELECTROPHORESIS
Volume 26, Issue 19, Pages 3716-3724

Publisher

WILEY
DOI: 10.1002/elps.200500173

Keywords

microfluidics; flow focusing; multiphase flow

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We experimentally study the production of micrometer-sized droplets using microfluidic technology and a flow-focusing geometry. Two distinct methods of flow control are compared: (i) control of the flow rates of the two phases and (ii) control of the inlet pressures of the two phases. In each type of experiment, the drop size l, velocity U and production frequency f are measured and compared as either functions of the flow-rate ratio or the inlet pressure ratio. The minimum drop size in each experiment is on the order of the flow focusing contraction width a. The variation in drop size as the flow control parameters are varied is significantly different between the flow-rate and inlet pressure controlled experiments.

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