Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 13, Issue 19, Pages 5592-5599Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.06.039
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Funding
- NCI NIH HHS [CA 82949] Funding Source: Medline
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We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia, Lewis lung carcinoma, and colon 38 adenocarcinoma. DHA-HCPT showed a greatly improved antitumor efficacy compared to HCPT. (c) 2005 Elsevier Ltd. All rights reserved.
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