Journal
SEMINARS IN CANCER BIOLOGY
Volume 15, Issue 5, Pages 353-364Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2005.05.005
Keywords
cancer-stromal interaction; epithelial to mesenchymal transition; 3-dimensional cell culture; prostate cancer bone metastasis; bone mineralization; cancer metastasis
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Funding
- NCI NIH HHS [CA82739, CA098912] Funding Source: Medline
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Cancer-stromal interaction results in the co-evolution of both the cancer cells and the surrounding host stromal cells. As a consequence of this interaction, cancer cells acquire increased malignant potential and stromal cells become more inductive. In this review we suggest that cancer-stromal interaction can best be investigated by three-dimensional (3D) co-culture models with the results validated by clinical specimens. We showed that 3D culture promoted bone formation in vitro, and explored for the first time, with the help of the astronauts of the Space Shuttle Columbia, the co-culture of human prostate cancer and bone cells to further understand the interactions between these cells. Continued exploration of cancer growth under 3D conditions will rapidly lead to new discoveries and ultimately to improvements in the treatment of men with hormonal refractory prostate cancer. (c) 2005 Elsevier Ltd. All rights reserved.
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