Journal
PEPTIDES
Volume 26, Issue 10, Pages 1972-1977Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2004.11.035
Keywords
MSH; proopiomelanocortin; hindbram; sex behavior
Funding
- NIDDK NIH HHS [R01 DK017420, R21 DK064112, 1 R21 DK 64112, R21 DK064112-01] Funding Source: Medline
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Melanocortin receptors in the forebrain and spinal cord can be activated by endogenous or synthetic ligands to induce penile erection in rats and human subjects. To better understand how melanocortin circuits play a role in sex behavior, we review the contribution of melanocortin receptors and/or neurons in the hypothalamus, hindbrain, spinal cord and peripheral nerves to erectile function. New information regarding neuropeptides that mediate penile erection has extended our understanding of the central control of sex behavior, and melanocortin agonists may provide alternatives to existing treatment for highly prevalent problems including erectile dysfunction. (c) 2005 Elsevier Inc. All rights reserved.
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