Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 58, Issue 11, Pages 6978-6981Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03648-14
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Funding
- NIH from the National Institute of Allergy and Infectious Diseases (NIAID) [R21 AI103260]
- Doctoral School on the Agro-Food System (Agrisystem) of the Universita Cattolica del Sacro Cuore (Italy)
- Regione Lombardia founding scheme GENOBACT [G41J10000400002]
- Fondazione Cariplo founding scheme BIOSAFE [2011-1414]
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During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs.
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