Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 347, Issue 11-13, Pages 1632-1642Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200505147
Keywords
indium; oxindoles; palladium; radicals; stereoselective; vinylindium
Categories
Ask authors/readers for more resources
The first efficient methods for the stereoselective synthesis of various (E), (Z)-, and disubstituted 3-alkylideneoxindoles via radical cyclization reactions were investigated using tandem indium-mediated carbometallation and palladium-catalyzed cross-coupling reactions. The proper combination of substrates and reaction conditions is important for good yields. The key step is the first stereoselective carboindation reaction using the strong coordination ability of an indium cation to the amide carbonyl oxygen. We applied this method to the synthesis of TMC95A precursor. A new N-debenzylation method with N-hydroxyphthalimide-O-2-Co(OAC)(2)-Mn(OAc)(2) was also developed using a one-electron oxidation procedure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available