Journal
NEUROSCIENCE RESEARCH
Volume 53, Issue 2, Pages 210-215Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2005.06.017
Keywords
neuroactive steroid; C-fibers; substance P; K+ channels; airway; guinea-pig
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We examined the effects of a neuroactive steroid, allotetrahydrocorticosterone on the activation of capsaicin-sensitive afferent sensory nerves (C-fibers). Allotetrahydrocorticosterone (0.0001-1.0 mu g/ml) dose-dependently inhibited electrical field stimulation-induced guinea-pig bronchial smooth muscle contraction, but not the substance P-induced contraction at 1.0 mu g/ml. Allotetrahydrocorticosterone (0.01-1.0 mu g/ml) also reduced the capsaicin-induced release of substance P-like immumoreactivity from guinea-pig airway tissues in a dose-dependent manner. The inhibitory effect of allotetrahydrocorticosterone on electrical field stimulation-induced bronchial contraction were reduced by the pretreatment of voltage-dependent K+ channel blockers, tetraethylammonium (1 mM). This evidence suggests that allotetrahydrocorticosterone negatively modulate the activation of C-fibers and substance P release from their endings in airway tissues via the opening of voltage-dependent K+ channels. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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