Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 58, Issue 2, Pages 1195-1199Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01779-13
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- National Center for Advancing Translational Sciences of the National Institutes of Health under Award [KL2TR000146]
- XDR Pathogen Laboratory by the University of Pittsburgh Medical Center
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We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistin-doripenem bactericidal activity against recurrent isolates was attenuated (mean log(10) kill, -5.74 versus -2.88; P = 0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus -2.43; P = 0.04).
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