Journal
NATURE IMMUNOLOGY
Volume 6, Issue 10, Pages 1047-1053Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1247
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI44259] Funding Source: Medline
Ask authors/readers for more resources
The cytokine thymic stromal lymphopoietin ( TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor - deficient mice had considerably attenuated disease. Lung-specific expression of a Tslp transgene induced airway inflammation and hyperreactivity characterized by T helper type 2 cytokines and increased immunoglobulin E. The lungs of Tslp-transgenic mice showed massive infiltration of leukocytes, goblet cell hyperplasia and subepithelial fibrosis. TSLP was capable of activating bone marrow - derived dendritic cells to upregulate costimulatory molecules and produce the T helper type 2 cell - attracting chemokine CCL17. These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available