Journal
NEUROSCIENTIST
Volume 11, Issue 5, Pages 408-416Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858405278865
Keywords
cerebral ischernia; neurogenesis; angiogenesis; restoration therapy
Categories
Funding
- NINDS NIH HHS [R01NS38292, P01 NS23393, P01 NS42345] Funding Source: Medline
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This article reviews current data on the induction of neurogenesis after stroke in the adult brain. The discussion of neurogenesis is divided into production, migration, and survival of these newly formed cells. For production, the subpopulations and the types of cell division are presented. Discussion of cell migration entails presenting data on both the pathways as well as the molecular targeting of newly formed neural progenitor cells to sites of injury. The role of the vascular and the astrocytic microenvironment in promoting the survival and integration of progenitor cells is also presented. Cell-based and pharmacological therapies designed to restore neurological function that promote neurogenesis are described. These therapies also induce angiogenesis and astrocytic changes that brain tissue, which prime the ischemic brain to foster the survival of the newly formed progenitor cells. Signaling pathways that regulate neurogenesis and angiogenesis are also addressed. This review summarizes recent data on neurogenesis and provides insight into the potential for restorative treatments of stroke.
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