Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 57, Issue 7, Pages 3441-3444Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00342-13
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- Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, Thailand
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The aim of this study was to reveal population pharmacokinetics and assess the efficacies of various dosage regimens of sulbactam in terms of the probability of target attainment with this agent over a range of MICs. Monte Carlo simulations were performed to determine the probability of attaining specific pharmacodynamic targets. The results indicated that a regimen consisting of a 4-h infusion of 3 g of sulbactam every 8 h would be an alternative treatment option for less-susceptible pathogens.
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