Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 57, Issue 7, Pages 3453-3456Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02454-12
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Funding
- European Research Council [202591]
- Welcome Trust
- Lendulet Program of the Hungarian Academy of Sciences
- European Research Council (ERC) [202591] Funding Source: European Research Council (ERC)
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Antibiotic resistance is generally selected within a window of concentrations high enough to inhibit wild-type growth but low enough for new resistant mutants to emerge. We studied de novo evolution of resistance to ciprofloxacin in an Escherichia coli knockout library. Five null mutations had little or no effect on intrinsic antibiotic susceptibility but increased the upper antibiotic dosage to which initially sensitive populations could adapt. These mutations affect mismatch repair, translation fidelity, and iron homeostasis.
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