Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 57, Issue 5, Pages 2365-2368Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02288-12
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Funding
- Pfizer [WS960288]
- Flemish Institute for Scientific Research (FWO) [G0804.11, WO.026.11N]
- FWO postdoctoral fellowship
- KU Leuven Postdoctoral fellowship [PDMK/11/089]
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This study addresses the effects of micafungin, caspofungin, and anidulafungin against Candida albicans biofilms developed in a subcutaneous catheter rat model system. Doses of 5, 10, and 30 mg/kg (of body weight)/day (the last only for micafungin) were given intravenously for 5, 7, and 10 days. All three echinocandins caused a significant reduction of the Candida cell numbers on the implanted catheters and are thus promising for the treatment of biofilm-related infections.
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