Efficient method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions

A simple, clean and highly efficient solvent-free procedure for the preparation of primary, secondary, tertiary and aromatic amides is described from the direct reaction of carboxylic acids and silica-supported ammonium salts, triethylamine (TEA) and tosyl chloride (TsCI) as condensing agent. The reaction proceeds rapidly in high yields at room temperature. (c) 2005 Elsevier Ltd. All rights reserved.