Journal
DEVELOPMENTAL BRAIN RESEARCH
Volume 159, Issue 2, Pages 135-143Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.devbrainres.2005.07.006
Keywords
heparan sulfate; sulfatase; in situ hybridization; floor plate; hippocampus; cerebral cortex
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A new class of sulfatases, SulfFP1/sulf-1 and SulfFP2/sulf-2, has been implicated in the modulation of extracellular signaling by remodeling heparan sulfate through 6-O-endosulfatase activity. Here, we isolated rat SulfFP2 cDNA and examined its expression by in situ hybridization. SulfFP2 expression is abundant and dynamically regulated in the nervous system during development, whereas it is confined to the cerebral cortex, hippocampal CA3 region, and medial habenular nucleus in the adult brain. (c) 2005 Elsevier B.V. All rights reserved.
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