Journal
PHYSICAL REVIEW LETTERS
Volume 95, Issue 15, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.95.158101
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We combine particle tracking and stochastic simulations to analyze the dynamics and organization of early endocytic vesicles in mammalian cells. At short time scales (< 10(1) sec) vesicles exhibit 1D symmetric bidirectional motor-driven transport on microtubules such that the mean squared displacement (MSD) scales as t(3/2), but the MSD shows a crossover to facilitated diffusion at longer times (> 10(1) sec). Facilitated diffusion results in rapid equilibration of vesicles on microtubules. The asterlike organization of microtubules causes perinuclear accumulation of vesicles despite symmetric transport.
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