Journal
SCIENCE
Volume 310, Issue 5745, Pages 111-113Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1117623
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Delta oscillations, characteristic of the electroencephalogram (EEG) of slow wave steep, estimate sleep depth and need and are thought to be closely linked to the recovery function of sleep. The cellular mechanisms underlying the generation of delta waves at the cortical and thalamic levels are well documented, but the molecular regulatory mechanisms remain elusive. Here we demonstrate in the mouse that the gene encoding the retinoic acid receptor beta determines the contribution of delta oscillations to the steep EEG. Thus, retinoic acid signaling, which is involved in the patterning of the brain and dopaminergic pathways, regulates cortical synchrony in the adult.
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