Journal
CELL
Volume 123, Issue 1, Pages 13-24Publisher
CELL PRESS
DOI: 10.1016/j.cell.2005.09.019
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Funding
- NCI NIH HHS [CA60499, R01 CA060499-12, R01 CA060499] Funding Source: Medline
- NIGMS NIH HHS [GM26108] Funding Source: Medline
- CGH CDC HHS [GH003157] Funding Source: Medline
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DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.
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