Journal
NEUROSCIENCE LETTERS
Volume 386, Issue 3, Pages 145-149Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.06.004
Keywords
pregnenolone; dehydroepiandrosterone (DHEA); microtubule-associated protein 2 (MAP-2); neonatal
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Neurosteroids administered during the neonatal period affect the development of several brain systems. We examined the effects of neonatal treatment with pregnenolone and dehydroepiandrosterone (DHEA) on a marker of neuronal dendrites, microtubule-associated protein 2 (MAP-2), in rat brain. Neonatal treatment with pregnenolone and DHEA increased the expression of MAP-2 in the hippocampus and nucleus accumbens but not in the prefrontal cortex, striatum or amygdala in adulthood. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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