Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 57, Issue 2, Pages 1053-1056Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01668-12
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Funding
- European Community's Seventh Framework Programme (FP7) under the project Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN)
- FWO grant [G.0611.09]
- Interuniversity Attraction Poles Programme, Belgian State, Belgian Science Policy [IAP-VI P6/41]
- research fund (PDM) of the KU Leuven
- Fonds voor Wetenschappelijk Onderzoek (FWO) Flanders
- Fundacao para a Ciencia e Tecnologia [SFRH/BPD/65605/2009]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/65605/2009] Funding Source: FCT
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Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.
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