4.7 Article

In Vivo Selection of Rifamycin-Resistant Clostridium difficile during Rifaximin Therapy

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 56, Issue 11, Pages 6019-6020

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00974-12

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We report the selection of Clostridium difficile resistant to the rifamycin class of antibiotics in a patient within 32 h of receiving rifaximin for the treatment of recurrent C. difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB.

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