Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 690, Issue 20, Pages 4488-4491Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2005.02.001
Keywords
artificial metalloenzymes; ruthenium; oxidation; piano stool complex; biotin-avidin technology
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Based on the incorporation of biotinylated organornetallic catalyst precursors within (strept)avidin, we have developed artificial metalloenzymes for the oxidation of secondary alcohols using tert-butylhydroperoxide as oxidizing agent. In the presence of avidin as host protein, the biotinylated aminosulfonamide ruthenium piano stool complex 1 (0.4 mol%) catalyzes the oxidation of sec-phenethyl alcohol at room temperature within 90 h in over 90% yield. Gel electrophoretic analysis of the reaction mixture suggests that the host protein is not oxidatively degraded during catalysis. (c) 2005 Elsevier B.V. All rights reserved.
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