Journal
TETRAHEDRON
Volume 61, Issue 41, Pages 9705-9709Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.06.067
Keywords
amination; anilines; aryl chlorides; palladium; phosphines
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Alkyl-di-(1-adamantyl)phosphonium salts are practical ligand precursors for the palladium-catalyzed amination of aryl chlorides. In the presence of typically 0.5 mol% Pd(OAc)(2) and 1 mol% of ligand precursor a variety of activated and deactivated aryl chlorides can be aminated in good to excellent yield (73-99%). Applying optimized conditions catalyst turnover numbers up to 10,000 have been achieved. (c) 2005 Elsevier Ltd. All rights reserved.
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