Journal
TETRAHEDRON LETTERS
Volume 46, Issue 41, Pages 7019-7022Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.08.047
Keywords
ultrasonication; A(3) coupling; propargylamine; water; copper salt
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Ultrasound was used for the addition of metal acetylides to in situ generated imines to generate propargylamines in good to excellent yields using copper iodide in water at ambient temperature. This process is an efficient alternative to traditional heated reactions. A variety of aldehydes and amines were used for this reaction. (c) 2005 Elsevier Ltd. All rights reserved.
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