Journal
TETRAHEDRON LETTERS
Volume 46, Issue 41, Pages 6995-6998Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.08.067
Keywords
H-D exchange; deuterium; Pt/C; aromatic ring; hydrogenation
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An effective and applicable Pt/C-catalyzed deuteration method of aromatic rings using D2O as a deuterium source under hydrogen atmosphere was developed. Five percent Pt/C would lead to quite effective H-D exchange results on the aromatic ring systems. The reaction is general for a variety of aromatic compounds including biologically active compounds. (c) 2005 Elsevier Ltd. All rights reserved.
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