Journal
FEBS LETTERS
Volume 579, Issue 24, Pages 5372-5378Publisher
WILEY
DOI: 10.1016/j.febslet.2005.08.075
Keywords
vascular endothelial growth factor; cold shock domain protein; Y-box protein; gene repression
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The hypoxia responsive region (HRR) of the VEGF promoter plays a key role in regulating VEGF expression. We found that the cold shock domain (Y-box) repressor proteins, dbpA and dbpB/YB-1, bind distinct strands of the human VEGF HRR. We find both dbpA and dbpB are phosphorylated by ERK2 and GSK3 beta in vitro, and the binding of dbpB to single-strand VEGF HRR DNA is regulated by this phosphorylation. These findings suggest the ERK/MAPK and PI3K pathways may regulate VEGF expression in part through regulating the action of these repressor proteins. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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