4.8 Article

Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines

Journal

ORGANIC LETTERS
Volume 7, Issue 21, Pages 4673-4676

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol051879w

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A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.

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