4.8 Article

Intermolecular Heck-type coupling of aryl iodides and allylic acetates

Journal

ORGANIC LETTERS
Volume 7, Issue 21, Pages 4745-4747

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol051947e

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A palladium-catalyzed arylation of allylic acetates followed by beta-acetoxy elimination was shown to produce Heck-type coupling products. Optimal reaction conditions employed ligand-free palladium on carbon in the presence of tetrabutylammonium chloride, a trialkylamine base, and water.

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