Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 57, Issue 2, Pages 1089-1091Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01781-12
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Funding
- University of Alabama at Birmingham (UAB) Center for AIDS Research (CFAR)
- NIH [P30 AI027767-24, R01 AI083632]
- National Science Foundation [ECCS 1128570]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1242765] Funding Source: National Science Foundation
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We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.
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