Journal
AIDS
Volume 19, Issue 15, Pages 1704-1706Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.aids.0000186823.76230.33
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Funding
- NIMH NIH HHS [MH62261, P30 MH062261, MH073490] Funding Source: Medline
- NINDS NIH HHS [F32 NS048830, NS045534] Funding Source: Medline
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The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.
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